AZETIDINE-DERIVED ESTERS, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF AS CANNABINOID RECEPTOR MODULATORS

摘要

The invention relates to the compounds of formula (I), where: R is a (C1-C6)alkyl or halo(C1-C6)alkyl group; A is a carbon atom optionally substituted by one or more hydrogen atoms or (C1-C6)alkyl groups; R5 is one or two carbon atoms substituted by one or more groups selected from among the hydroxy, (C1-C6)alkoxy, OCOR2, OCOOR6, or NRaRb groups or a heterocyclic group optionally substituted by a halogen atom or a (C1-C6)alkyl, halo(C1-C6)alkyl, (C1-C6)alkoxy, or oxo group; R1 is a hydrogen atom or a (C1-C6)alkyl group; R2 is a hydrogen atom or a (C1-C6)alkyl group; each of R3 and R4 is a phenyl group optionally substituted by one or more atoms or groups selected from among a hydrogen atom, a halogen atom, a (C1-C6)alkyl group, a (C1-C6)alkoxy group, a halo(C1-C6)alkoxy group, or a cyano group; R6 is a (C1-C6)alkyl group; Ra and Rb are, independently of each other, a hydrogen atom or a (C1-C6)alkyl group; Y is a hydrogen atom, a halogen, a (C1-C6)alkyl group, a halo(C1-C6)alkyl group, a (C1-C6)alkoxy group, a halo(C1-C6)alkoxy group, a (C1-C6)alkylS(0)p group, or a cyano group; and p is between 0 and 2 in the state of a base or of an acid addition salt. The invention also relates to a method for preparing same to the therapeutic use thereof.