POLYAMINE TRANSPORT INHIBITORS AS NOVEL THERAPEUTICS
摘要
Novel polyamine transport inhibitors have been synthesized and demonstrated to block the uptake of native polyamines into human cancer cells. A combination therapy of the transport inhibitor and DFMO (a drug which blocks polyamine biosynthesis) provided synergistic activity against a metastatic human colon cancer cell line. The strategy uses polyamine depletion and polyamine metabolism to generate reactive oxygen species within cells as a novel way to treat cancers. This approach may be implemented for widespread use in the treatment of diseases which rely upon polyamine transport activity for proliferation.
申请公布号
WO2010148390(A2)
申请公布日期
2010.12.23
申请号
WO2010US39334
申请日期
2010.06.21
申请人
UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC.;PHANSTIEL, OTTO;ARCHER, JENNIFER, J.