发明名称 |
METHOD FOR DETERMINATION OF A POTENTIAL MUTATION |
摘要 |
The invention is directed to a method for non-invasive determination of the potential presence of one or more loss-of-function mutation(s) in the gene encoding for filaggrin. The method of the invention comprises (i) obtaining a vibrational spectrum from the stratum corneum of the individual; (ii) determining the local natural moisturising factor content from the vibrational spectrum; (iii) optionally repeating steps (i) and (ii); and (iv) comparing the local natural moisturising factor content of the individual to a reference value, wherein said stratum corneum is stratum corneum of a location of the body of said individual at which said one or more loss-of-function mutation(s) in the gene encoding for filaggrin has a stronger influence on the natural moisturising factor concentration than other factors influencing the natural moisturising factor concentration.
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申请公布号 |
US2010322860(A1) |
申请公布日期 |
2010.12.23 |
申请号 |
US20080666311 |
申请日期 |
2008.06.25 |
申请人 |
CASPERS PETER JACOBUS;THIO HOK BING;PUPPELS GERWIN JAN;KEMPERMAN PATRICK M J H;NEUMANN HENDRIK ARENT MARTINO |
发明人 |
CASPERS PETER JACOBUS;THIO HOK BING;PUPPELS GERWIN JAN;KEMPERMAN PATRICK M.J.H.;NEUMANN HENDRIK ARENT MARTINO |
分类号 |
A61K49/00;A61P43/00;G01N33/483 |
主分类号 |
A61K49/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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