| 摘要 |
A hemostatic material (100), production method, delivery method, and apparatus are disclosed. The hemostatic material (100) includes a peptide (106a) that preferentially selects exposed endothelial cells for bonding. The peptide (106a) is conjugated with a hemostatic agent (e.g., chitosan) (108a) to produce a peptide conjugated hemostatic agent (110a). The peptide conjugated hemostatic agent (110a) is suspended in a flowable delivery medium (116) that delivers the material to the endothelial cells to stop or reduce bleeding. An apparatus for delivering the hemostatic material (100) includes a conformable covering for sealing off and maintaining an internal pressure in an injury cavity, a delivery port for delivering hemostatic material (100) into the cavity, and a check valve that opens when a predetermined pressure is reached. Methods for producing the hemostatic material (100) and using the apparatus are also disclosed herein. |
