OLIGOMERIC COMPOUNDS FOR THE MODULATION OF HIF-1ALPHA EXPRESSION

摘要

Oligonucleotides directed against the hypoxia-inducible factor-1± (HIF-1±) gene are provided for modulating the expression of HIF-1±. The compositions comprise oligonucleotides, particularly antisense oligonucleotides, targeted to nucleic acids encoding the HIF-1±. Methods of using these compounds for modulation of HIF-1± expression and for the treatment of diseases associated with the hypoxia-inducible factor-1± are provided. Examples of diseases are cancer and pre-eclampsia. The oligonucleotides may be composed of deoxyribonucleosides, a nucleic acid analogue, or Locked Nucleic Acid (LNA) or a combination thereof.