发明名称 |
METHOD FOR GENERATING ISLET BETA CELLS FROM DEDIFFERENTIATED EXOCRINE PANCREATIC CELLS |
摘要 |
<p>The present invention relates to an in vitro method for generating insulin-producing beta cells from a population of mammalian cells comprising dedifferentiated exocrine pancreatic cells. The method comprises the step of culturing said dedifferentiated exocrine pancreatic cells in a culture medium in the presence of at least one agent that is able to inhibit the Notch 1 signaling pathway in said dedifferentiated exocrine pancreatic cells, and at least one ligand of the gp130 receptor and/or at least one ligand of the EGF receptor. The invention further provides a population of mammalian pancreatic cells comprising insulin-producing beta cells obtainable by the present method and uses thereof in a pharmaceutical composition for treating type 1 or type 2 diabetes.</p> |
申请公布号 |
EP2262890(A1) |
申请公布日期 |
2010.12.22 |
申请号 |
EP20090711597 |
申请日期 |
2009.02.11 |
申请人 |
VRIJE UNIVERSITEIT BRUSSEL;OPUS NV |
发明人 |
BOUWENS, LUC;BAEYENS, LUC |
分类号 |
C12N5/07;A61K35/39;A61P5/48;C12N5/071;(IPC1-7):C12N5/06 |
主分类号 |
C12N5/07 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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