TARGETED GENOMIC REARRANGEMENTS USING SITE-SPECIFIC NUCLEASES

摘要

PURPOSE: A method for rearrangement of genomic DNA is provided to change specific gene using zinc-finger nuclease. CONSTITUTION: A target-specific nuclease is used in deletion, duplication, inversion, or rearrangement of genomic DNA by two or more cleaving specific sites. The target-specific nuclease is a zinc finger nuclease. The zinc finger nuclease contains two or more zinc finger modules. The zinc finger nuclease recognizes different two sites.