A method for enhancing the mixing of materials in roller bottle by the introduction of controlled axial and cross-sectional flow perturbations is disclosed. The effectiveness of the method is demonstrated by achieving higher efficiency in cell culturing and virus propagation in roller bottles by introducing controlled flow perturbations during the process.
申请公布号
CA2308111(C)
申请公布日期
2010.12.21
申请号
CA19982308111
申请日期
1998.10.27
申请人
MERCK & CO., INC.;RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
发明人
BRAMBLE, JOYE L.;SEARLES, JAMES A.;MUZZIO, FERNANDO J.