ANTI-ADHESION AGENT COMPRISING EPOXIDE-CROSSLINKED HYALURONIC ACID DERIVATIVE HYDROGEL AND PROCESS FOR PRODUCING THE SAME

摘要

PURPOSE: An anti-adhesion agent containing hyaluronic acid epoxide derivative hydrogel and a method for manufacturing the same are provided to prevent adhesion between tissues without side effects. CONSTITUTION: An anti-adhesion agent contains hyaluronic acid epoxide derivative hydrogen. The particle size of the hydrogel is 100-300 um. The viscosity and crosslinking density of the hydrogel are 100,000 cP (0.02 Hz)-6,000,000 cP (0.02 Hz) and 0.2 mol%-100 mol%, respectively. The hydrogel is prepared by reacting hyaluronic acid and epoxide crosslinking agent in NaOH solution or crossliking 0.1-200 weight parts of crosslinking agent based on 100 weight parts of repeat unit of the hyaluronic acid.