CONJUGATES OF CELL- PENETRATING PEPTIDES AND PHOSPHORESCENT METALLOPORPHYRINS FOR INTRACELLULAR OXYGEN MEASUREMENT

摘要

A phosphorescent compound of general Formula (I), or phosphorescent analogs thereof, wherein: -at least one of R1 to R4 has a formula X-Y, wherein Y is a peptide sequence providing cell penetration, and X is absent or is a chemical linker; -the or each of the remaining R1 to R4 groups are, independently, lipophilic, uncharged chemical groups; and -Me is selected from Pt2+ or Pd2+, which probe is capable of measurement of molecular oxygen within live respiring cells by quenched-phosphorescence detection.