| 摘要 |
Disclosed are compounds having the formula (I): wherein the R1, R2, R3, X, Y, A, L, and G are defined herein. These compounds bind to aspartic proteases to inhibit their activity and are useful in the treatment or amelioration of diseases associated with aspartic protease activity. Also disclosed are methods of use of the compounds of Formula I for ameliorating or treating aspartic protease related disorders in a subject in need thereof.
|
| 申请人 |
BALDWIN JOHN J;CACATIAN SALVACION;CLAREMON DAVID;DILLARD LAWRENCE W;FLAHERTY PATRICK T;GHAVIMI-ALAGHA BAHMAN;GHIRLANDA DAMIANO;ISHCHENKO ALEXEY V;KALLANDER LARA S;LAWHORN BRIAN;LU QING;MCGEEHAN GERARD;KNAPP-REID BETH A;SEMUS SIMON;SIMPSON ROBERT D;SINGH SURESH B;TERRELL LAMONT R;TICE COLIN;TRAN TRITIN;XU ZHERONG;YUAN JING;ZHAO WEI;ZHAO YONGDONG Y |
发明人 |
BALDWIN JOHN J.;CACATIAN SALVACION;CLAREMON DAVID;DILLARD LAWRENCE W.;FLAHERTY PATRICK T.;GHAVIMI-ALAGHA BAHMAN;GHIRLANDA DAMIANO;ISHCHENKO ALEXEY V.;KALLANDER LARA S.;LAWHORN BRIAN;LU QING;MCGEEHAN GERARD;KNAPP-REID BETH A.;SEMUS SIMON;SIMPSON ROBERT D.;SINGH SURESH B.;TERRELL LAMONT R.;TICE COLIN;TRAN TRITIN;XU ZHERONG;YUAN JING;ZHAO WEI;ZHAO YONGDONG Y. |
