DERIVATIVES OF MEFLOQUINE AND ASSOCIATED METHODS FOR MAKING AND USING
摘要
<p>The present invention relates to new mefloquine derivatives and therapeutic compositions comprising one or more mefloquine derivatives. Mefloquine derivatives of the invention have a pentafluorosulfanyl moiety substitution at the 8-position. Certain mefloquine derivatives further include a quinoline methanol moiety substitution at the 4-position. The present invention also relates to new intermediate compounds useful in the synthesis of the mefloquine derivatives, which intermediates also have a pentafluorosulfanyl moiety substitution at the 8-position.</p>
申请公布号
WO2010144434(A1)
申请公布日期
2010.12.16
申请号
WO2010US37752
申请日期
2010.06.08
申请人
THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE ARMY, ON BEHALF OF U.S.;DOW, GEOFFREY, S.;MILNER, ERIN, E.;WIPF, PETER;MO, TINGTING