NUCLEIC ACID SEQUENCES COMPRISING NF-kB BINDING SITE WITHIN O(6)-METHYLGUANINE-DNA-METHYLTRANSFERASE (MGMT) PROMOTER REGION AND USES THEREOF FOR THE TREATMENT OF CANCER AND IMMUNE-RELATED DISORDERS

摘要

The invention relates to nucleic acid sequences comprising NF-&kgr;B binding sites derived from the MGMT promoter region and uses thereof as decoy molecules in the treatment of cancer and immune-related disorders. More particularly, the invention relates to nucleic acid sequences as well as to modified oligonucleotides (ODNs) comprising NF-&kgr;B binding sites derived from the MGMT promoter region, and uses thereof as decoy molecules for inhibiting NF-&kgr;B enhanced expression of MGMT. The invention further relates to compositions, kits and screening methods using the NF-&kgr;B binding sites of the invention or ODNs comprising the same for treating cancer and immune related disorders.