| 发明名称 |
NOVEL SULFONAMIDOMETHYLPHOSPHONATE INHIBITORS OF BETA-LACTAMASE |
| 摘要 |
This invention provides novel &bgr;-lactamase inhibitors of the aryl- and heteroaryl-sulfonamidomethylphosphonate monoester class. The compounds inhibit three classes of &bgr;-lactamases and synergize the antibacterial effects of &bgr;-lactam antibiotics (e.g., imipenem and ceftazimdime) against those micro-organisms normally resistant to the &bgr;-lactam antibiotics as a result of the presence of the &bgr;-lactamases.
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| 申请公布号 |
US2010317625(A1) |
申请公布日期 |
2010.12.16 |
| 申请号 |
US20070301793 |
申请日期 |
2007.05.21 |
| 申请人 |
DININNO FRANK;HAMMOND MILTON L;DYKSTRA KEVIN;KIM SEONGKON;TAN QIANG;YOUNG KATHERINE;HERMES JEFFREY DONALD;RAEPPEL STEPHANE;MANNION MICHAEL;ZHOU NANCY Z;GAUDETTE FREDERIC;VAISBURG ARKADII;RAHIL JUBRAIL;GEORGOPAPADAKOU NAFSIKA |
发明人 |
DININNO FRANK;HAMMOND MILTON L.;DYKSTRA KEVIN;KIM SEONGKON;TAN QIANG;YOUNG KATHERINE;HERMES JEFFREY DONALD;RAEPPEL STEPHANE;MANNION MICHAEL;ZHOU NANCY Z.;GAUDETTE FREDERIC;VAISBURG ARKADII;RAHIL JUBRAIL;GEORGOPAPADAKOU NAFSIKA |
| 分类号 |
A61K31/675;A61K31/665;A61K31/67;A61P31/04;C07F9/6539;C07F9/655;C07F9/6553;C07F9/6561 |
主分类号 |
A61K31/675 |
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