| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide immunogenic and pharmaceutical compositions for the treatment and prevention of human papillomavirus (HPV)-associated cancers, in particular, cervical cancer. <P>SOLUTION: Human papillomavirus E6 and/or E7 provides fusions of HPV E6 and E7 which discard the transformation activity of the cancer gene proteins due to one or more mutation and, thus, confer safety to the E6/E7 fusions. In addition, these fusions maintain or increase the immunogenic efficacy of E6 and E7. Any gene or protein delivery method can be used to deliver or package the immunogenic compositions. <P>COPYRIGHT: (C)2011,JPO&INPIT |
