发明名称 |
COMPOUNDS WITH MDR1-INVERSE ACTIVITY |
摘要 |
Disclosed herein are drug compounds that have MDR-inverse activity and thus are effective against multidrug-resistant cells. Exemplary compounds disclosed herein have the structure: Examples of the disclosed compounds have been found to have, inter alia, efficacy in directly treating multidrug resistant cells, rendering multidrug resistant cells susceptible to other chemotherapeutics and in some instances reversing multidrug resistance.
|
申请公布号 |
US2010316655(A1) |
申请公布日期 |
2010.12.16 |
申请号 |
US20090867206 |
申请日期 |
2009.02.10 |
申请人 |
HALL MATTHEW D;GOTTESMAN MICHAEL M;HELLAWELL JENNIFER L;LUDWIG JOSEPH A;FALES HENRY M;SALAM NOERIS K;SZAKACS GERGELY |
发明人 |
HALL MATTHEW D.;GOTTESMAN MICHAEL M.;HELLAWELL JENNIFER L.;LUDWIG JOSEPH A.;FALES HENRY M.;SALAM NOERIS K.;SZAKACS GERGELY |
分类号 |
A61K39/395;A61K31/175;A61K31/337;A61K31/351;A61K31/403;A61K31/404;A61K31/437;A61K31/44;A61K31/506;A61K31/704;A61K31/7048;A61K31/7068;A61K38/12;A61P35/00;A61P35/02 |
主分类号 |
A61K39/395 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|