发明名称 |
HIV-1 Envelope Glycoprotein Oligomer and Methods of Use |
摘要 |
This invention relates to fusion polypeptides comprised of a trimerization domain fused to a non-membrane bound, non-cleaved gp160 polypeptide derived from the R2 HIV-1 Env glycoprotein and to compositions comprising the fusion polypeptides. This invention further relates to oligomers of the fusion polypeptides. This invention also relates to nucleic acids encoding the fusion polypeptides. This invention also relates to diagnostic and therapeutic methods using the fusion polypeptides. Further, this invention relates to the induction of cross-reactive neutralizing antibodies against HIV-1, and to immunogenic compositions for the prevention and treatment of infection by HIV-1.
|
申请公布号 |
US2010316661(A1) |
申请公布日期 |
2010.12.16 |
申请号 |
US20080742272 |
申请日期 |
2008.11.12 |
申请人 |
QUINNAN GERALD;BRODER CHRISTOPHER |
发明人 |
QUINNAN GERALD;BRODER CHRISTOPHER |
分类号 |
A61K39/00;A61P37/04;C07H21/04;C07K14/00;C07K16/00 |
主分类号 |
A61K39/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|