发明名称 |
Methods and Compositions for Inhibiting Cell Death or Enhacing Cell Proliferation |
摘要 |
The present invention provides compositions and methods that enhance cell survival. Such compositions feature chimeric polypeptides that include at least a GM-CSF receptor ligand and an anti-apoptotic moiety (e.g., a Bcl-2 protein family member). In one embodiment, the chimeric polypeptide is a GM-CSF-Bcl-xL chimeric polypeptide. The invention further includes methods of using chimeric polypeptides to enhance cell survival or inhibit cell death in a cell at risk of cell death.
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申请公布号 |
US2010317577(A1) |
申请公布日期 |
2010.12.16 |
申请号 |
US20060991692 |
申请日期 |
2006.09.08 |
申请人 |
DEPARTMENT OF HEALTH AND HUMAN SERVICES |
发明人 |
YOULE RICHARD J;ANTIGNANI ANTONELLA |
分类号 |
A61K38/18;A61P25/28;C07H21/04;C07K7/06;C07K7/08;C07K14/535;C12N5/071;C12N15/63;G01N33/53 |
主分类号 |
A61K38/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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