发明名称 |
METHOD FOR SCREENING COMPOUNDS FOR THE TREATMENT OR PREVENTION OF COLON CANCER |
摘要 |
<p>The invention is in the field of molecular medicine, more in particular in the field of identifying new compounds for the treatment or prevention of colorectal cancer. The invention provides a method for the screening and/or identification of compounds that are capable of preventing or ameliorating the adverse effects of reactive oxygen species on eukaryotic cells. More in particular, the invention provides a method for the identification of an active therapeutic compound for preventing or ameliorating the adverse effects of reactive oxygen species on eukaryotic cells comprising the steps of:providing an assay wherein the expression of the WNT pathway in Caco cells can be determined under the influence of a reactive oxygen species, providing a candidate therapeutic compound, determining the ability of said therapeutic compound to normalize the expression of said WNT pathway in the presence or absence of said oxidant.</p> |
申请公布号 |
WO2010142783(A1) |
申请公布日期 |
2010.12.16 |
申请号 |
WO2010EP58225 |
申请日期 |
2010.06.11 |
申请人 |
UNIVERSITEIT MAASTRICHT;KLEINJANS, JOSEPH CATHARINA STEPHANUS;BRIEDE, JACOB JAN;ACADEMISCH ZIEKENHUIS MAASTRICHT |
发明人 |
KLEINJANS, JOSEPH CATHARINA STEPHANUS;BRIEDE, JACOB JAN |
分类号 |
G01N33/50 |
主分类号 |
G01N33/50 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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