DEVICES AND METHODS FOR ANALYZING BIOMOLECULES AND PROBES BOUND THERETO

摘要

Methods for sequencing biomolecules include improving signal-to-noise ratio of detection of relative positions of probes hybridized to a biomolecule by coating at least a portion of the biomolecule (125) with a protein prior to its translocation through a nanopore (1750), nanochannel (105), or microchannel (105). The apparatus (100) comprising the nanopore (1750), nanochannel (105), or microchannel (105) further comprises driving force generater, e.g. an electromotive electrode pair (110, 110') and electrodes (115A, 115B) defining a detector volume and being in communication with an electrical signal detector (120).