| 摘要 |
<p>Disclosed is a Hepatitis C virus (HCV) vaccine comprising at least two epitopes, each from a different hotspot epitope, wherein a hotspot epitope is defined as an epitope containing peptide selected from the group consisting of
KFPGGGQIVGGVYLLPRRGPRLGVRATRK,
GYKVLVLNPSVAAT,
AYAAQGYKVLVLNPSVAAT,
DLMGYIP(A/L)VGAPL,
GEVQVVSTATQSFLATCINGVCWTV,
HMWNFISGIQYLAGLSTLPGNPA,
VDYPYRLWHYPCT(V/I)N(F/Y)TIFK(V/I)RMYVGGVEHRL,
AAWYELTPAETTVRLR,
GQGWRLLAPITAYSQQTRGLLGCIV,
IGLGKVLVDILAGYGAGVAGALVAFK,
FTDNSSPPAVPQTFQV,
LEDRDRSELSPLLLSTTEW,
YLVAYQATVCARAQAPPPSWD,
MSTNPKPQRKTKRNTNR,
LINTNGSWHINRTALNCNDSL,
TTILGIGTVLDQAET,
FDS(S/V)VLCECYDAG(A/C)AWYE,
ARLIVFPDLGVRVCEKMALY,
AFCSAMYVGDLCGSV,
GVLFGLAYFSMVGNW,
VVCCSMSYTWTGALITPC,
TRVPYFVRAQGLIRA and
TTLLFNILGGWVAAQ.</p> |
