| 摘要 |
An oral adjuvant for pharmaceutical immunogen delivery, drug delivery devices comprising the adjuvant and methods of treatment using pharmaceutical formulations comprising the adjuvant (e.g. to treat Th1 cell mediated diseases) are disclosed wherein the adjuvant comprises a lipid and an alcohol arranged to stimulate uptake of the immunogen by dendritic cells and or macrophages. Preferably the adjuvant comprises at least 30% wax, lipid of oil and ethanol, preferably the lipid is linseed oil and preferably the adjuvant further comprises an NSAID such as ibuprofen or a PPAR-gamma agonist. The effects of ibuprofen formulated in 90% linseed oil, 10% ethanol on the survival of influenza challenged mice and a vaginal pessary comprising the ibuprofen formulation intended for administration to prevent premature labour are disclosed.
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