Preparation of polyhalogenated perhaloalkylaniline useful as intermediate for the synthesis of agrochemicals by reacting benzene containing compound with ammonia in the presence of potassium fluoride, and reacting with halogenating agent

摘要

Preparing polyhalogenated perhaloalkylaniline comprises reacting, in a polar solvent from N-methylpyrrolidone, dimethylsulfone, N,N-dimethylimidazolidinone or diphenyl sulfone, preferably N-methylpyrrolidone, a benzene containing compound with ammonia, in the presence of an alkali halide, preferably potassium fluoride, at 200-300, preferably 235-250[deg] C and 20-50, preferably 25-42 kg/cm 2>to form 2-halo-perhaloalkyl aniline; and#reacting 2-halo-perhaloalkylaniline formed in step (A) with a halogenating agent to form a polyhalogenated perhaloalkylaniline. Preparing polyhalogenated perhaloalkylaniline comprises: (A) reacting, in a polar solvent from N-methylpyrrolidone, dimethylsulfone, N,N-dimethylimidazolidinone or diphenyl sulfone, preferably N-methylpyrrolidone, a compound of formula (I) with ammonia, in the presence of an alkali halide, preferably potassium fluoride, at 200-300, preferably 235-250[deg] C and 20-50, preferably 25-42 kg/cm 2>to form 2-halo-perhaloalkyl aniline; and (B) reacting 2-halo-perhaloalkylaniline formed in step (A) with a halogenating agent to form a polyhalogenated perhaloalkylaniline. R 1, R 2halo; and R 3perhaloalkyl. [Image].