发明名称 |
Protein purification method |
摘要 |
Problems to be Solved: The present invention provides a simpler and less expensive method for purifying physiologically active proteins, especially antibodies, which can ensure removal of impurities such as DNA contaminants and viruses, and which can minimize a loss of physiologically active proteins. Means for Solving the Problems: A method for removing impurities in a physiologically active protein-containing sample, which comprises the following steps:
1) allowing the physiologically active protein-containing sample to be converted into an aqueous solution of low conductivity at a pH below the isoelectric point of the physiologically active protein; and
2) removing the resulting particles. |
申请公布号 |
EP2261230(A1) |
申请公布日期 |
2010.12.15 |
申请号 |
EP20100180577 |
申请日期 |
2003.09.11 |
申请人 |
CHUGAI SEIYAKU KABUSHIKI KAISHA |
发明人 |
TAKEDA, KOZO;OCHI, NORIMICHI;ISHII, KIMIE;MATSUHASHI, MANABU;IMAMURA, AKINORI |
分类号 |
C07K1/30;C07K1/22;C07K1/34;C07K16/00;C07K16/06;C07K16/26;C07K16/28;C07K16/30 |
主分类号 |
C07K1/30 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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