METHOD FOR HIGH-LEVEL SECRETION AND PRODUCTION OF PROTEIN
摘要
This invention provides a means for high-level secretory production of a protein, and, in particular, a protein having a complicated structure such as an antibody, in a host cell such as a yeast cell. This invention provides a method for high-level secretory production of a foreign protein with the use of a transformed host cell having one or more types of chaperone protein genes and via suppression of O sugar chain inherent to a host cell such as a yeast cell.
申请公布号
EP2210940(A4)
申请公布日期
2010.12.15
申请号
EP20080845087
申请日期
2008.10.29
申请人
DAIICHI SANKYO COMPANY, LIMITED;KYOWA HAKKO KIRIN CO., LTD.