发明名称 |
METHODS OF IDENTIFYING ANTI-INFLAMMATORY COMPOUNDS. |
摘要 |
<p>A mammalian C-type lectin receptor type is identified which is shown to bind IgG antibodies or Fc fragments, thus inducing IVIG-related reversal of inflammation associated with various immune disorders. The identification of a DC- SIGN receptor type which interacts with IgG to promote a biological response reducing inflammation associated with immune disorders provides for methods of screening and selecting compounds which may be useful in treating various immune disorders by acting to modulate a DC-SIGN1+1 cell to signal a second effector macrophage, causing an increase in expression of the FcγRIIB receptor and in turn inhibiting a cellular-mediated inflammatory response.</p> |
申请公布号 |
MX2010011598(A) |
申请公布日期 |
2010.12.15 |
申请号 |
MX20100011598 |
申请日期 |
2009.04.22 |
申请人 |
THE ROCKEFELLER UNIVERSITY. |
发明人 |
JEFFREY V. RAVETCH;ROBERT M. ANTHONY |
分类号 |
G01N33/48 |
主分类号 |
G01N33/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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