发明名称 |
STIM2-MEDIATED CAPACITIVE CALCIUM ENTRY |
摘要 |
<p>The present invention relates to a pharmaceutical composition comprising an inhibitor of STIM2 or an inhibitor of STIM2-regulated plasma membrane calcium channel activity and optionally a pharmaceutically acceptable carrier, excipient and/or diluent. Furthermore, the present invention relates to an inhibitor of STIM2 or an inhibitor of STIM2-regulated plasma membrane calcium channel activity for the treatment and/or prevention of a neurological disorder associated with pathologically increased cytosolic calcium concentrations. The present invention also relates to a method of treating and/or preventing a neurological disorder associated with pathologically increased cytosolic calcium concentrations comprising administering a pharmaceutically effective amount of an inhibitor of STIM2 or of an inhibitor of STIM2-regulated plasma membrane calcium channel activity to a subject in need thereof. The present invention further relates to methods of identifying a compound suitable as a lead compound and/or as a medicament for the treatment and/or prevention of a neurological disorder associated with pathologically increased cytosolic calcium concentrations.</p> |
申请公布号 |
WO2010136577(A1) |
申请公布日期 |
2010.12.02 |
申请号 |
WO2010EP57443 |
申请日期 |
2010.05.28 |
申请人 |
CSL BEHRING GMBH;JULIUS-MAXIMILIANS-UNIVERSITAET-WUERZBURG;NIESWANDT, BERNHARD;STOLL, GUIDO |
发明人 |
NIESWANDT, BERNHARD;STOLL, GUIDO |
分类号 |
A61K39/395;C07K16/18;C12N15/113 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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