RESOLUTION OF (±)-METHYL PHENYL[4-[4-[[[4'-(TRIFLUOROMETHYL)-2-BIPHENYLYL]CARBONYL]AMINO]PHENYL]-1-PIPERIDINYL]ACETATE
摘要
The present invention relates to a resolution process of (±)-methyl phenyl[4-[4-[[[4'-(trifluoromethyl)-2-biphenylyl]carbonyl]amino]phenyl]-1-piperidinyl]acetate to isolate the MTP (microsomaltriglyceride transfer protein) inhibitor methyl (2S)-phenyl[4-[4-[[[4'-(trifluoromethyl)-2-biphenylyl]carbonyl]amino]phenyl]-1-piperidinyl]-acetate and an epimerisation procedure for racemizing methyl (2R)-phenyl[4-[4-[[[4'-(trifluoromethyl)-2-biphenylyl]carbonyl]amino]phenyl]-1-piperidinyl]acetate.
申请公布号
CA2757702(A1)
申请公布日期
2010.12.02
申请号
CA20102757702
申请日期
2010.05.27
申请人
JANSSEN PHARMACEUTICA NV
发明人
COPMANS, ALEX HERMAN;HOET, JEROME ALBERT JOSEPH;WILLEMSENS, ALBERT LOUIS ANNA;COUCK, WOUTER LOUIS J.;VAN DUN, JOANNES PETRUS