发明名称 |
DRUG DELIVERY SYSTEMS USING FC FRAGMENTS |
摘要 |
The present invention provides drug delivery systems comprising FcRn binding partners (e.g., FcRn binding partner, Fc fragment) associated with a particle or an agent to be delivered. Inventive drug delivery systems allow for binding to the FcRn receptor and transcytosis into and/or through a cell or cell layer. Inventive systems are useful for delivering therapeutic agents across the endothelium of blood vessels or the epithelium of an organ.
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申请公布号 |
US2010303723(A1) |
申请公布日期 |
2010.12.02 |
申请号 |
US20070515465 |
申请日期 |
2007.11.20 |
申请人 |
MASSACHUSETTS INSTITUTE OF TECHNOLOGY;THE BRIGHAM AND WOMEN'S HOSPITAL, INC. |
发明人 |
FAROKHZAD OMID C.;ALEXIS FRANK;KUO TIMOTHY T.;PRIDGEN ERIC;RADOVIC-MORENO ALEKSANDAR FILIP;LANGER ROBERT S. |
分类号 |
A61K9/127;A61K9/14;A61K38/21;A61K39/395;A61K49/00;A61P9/00;C07K14/555;C07K16/00;C12N9/96 |
主分类号 |
A61K9/127 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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