| 摘要 |
Artificial (e.g., synthetic) carbohydrate receptors that specifically bind sialic acid and cancer cell surface carbohydrate antigens containing terminal sialic moieties (e.g., Lewis oligosacharide antigens) and methods of use were developed. The artificial carbohydrate receptors and methods can be used to detect and identify biologically important carbohydrates, selectively label cancer cells, to modulate cancer cell growth, and to modulate inflammation. Because the artificial carbohydrate receptors demonstrate a strong affinity for sialylated Lewis oligosacharide antigens (e.g., sialyl Lewis x (sLex) and sialyl Lewis a (sLea)) which are overexpressed on tumor cells during the onset and progression of cancer, and are overexpressed on the endothelium of chronically inflamed tissues, the artificial carbohydrate receptors described herein can find use as cancer diagnostic and therapeutic agents. |
