E-CADHERIN AS A BIOMARKER OF GASTROESOPHAGEAL REFLUX DISEASE
摘要
The present invention provides methods of diagnosing and identifying subjects as having GERD comprising detecting E-cadherin fragments in a biological sample from the subject. The invention further provides methods for identifying subjects as having heartburn that is responsive to proton pump inhibitor therapy and subjects having an increased likelihood of a rapid relapse of GERD after reducing the dosage of PPIs or terminating PPI therapy. In addition, the present invention provides methods for monitoring the healing of erosive and nonerosive esophagitis of GERD without the need for esophagogastroduodenoscopy or esophagogastroduodenoscopy and biopsy, respectively.
申请公布号
WO2010138851(A2)
申请公布日期
2010.12.02
申请号
WO2010US36634
申请日期
2010.05.28
申请人
THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL;ORLANDO, ROY C.;JOVOV, BILJANA;TOBEY, NELIA A.;ORLANDO, GERALDINE S.;DJUKIC, ZORKA
发明人
ORLANDO, ROY C.;JOVOV, BILJANA;TOBEY, NELIA A.;ORLANDO, GERALDINE S.;DJUKIC, ZORKA