发明名称 |
Method for the Production of 1,3-Dioxolane-2-Ones and Carboxylic Acid Esters by Means of Transacylation in Basic Reaction Conditions |
摘要 |
The invention relates to a method for producing 1,3-dioxolane-2-ones of general formula (3) in basic reaction conditions by reesterifying the respective ester of general formula (1) in which R1 to R5 have the meanings indicated in the claims and the description. The invention further relates to a method for producing 2-hydroxy carboxylic acid esters of general formula (5) with or without isolation of the intermediate in the form of a derivative of the 1,3-dioxolane-2-one of general formula (3) in basic reaction conditions by reesterifying the respective ester of general formula (1) in which R1, R2, and R6 have the meanings indicated in the claims and the description. The method according to the invention allows the reaction to take place in very gentle basic conditions, causing fewer secondary reactions and providing a greater yield than reactions in highly polar aprotic solvents. Acid-sensitive and/or temperature-sensitive compounds can be synthesized.
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申请公布号 |
US2010305146(A1) |
申请公布日期 |
2010.12.02 |
申请号 |
US20080677920 |
申请日期 |
2008.09.03 |
申请人 |
BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG |
发明人 |
BRANDENBURG JOERG;DACH ROLF;BALTES HANFRIED |
分类号 |
A61K31/438;A61P11/06;C07D409/06;C07D451/02;C07D491/113 |
主分类号 |
A61K31/438 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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