IN VITRO DIAGNOSIS/PROGNOSIS METHOD AND KIT FOR ASSESSMENT OF TOLERANCE IN LIVER TRANSPLANTATION

摘要

This invention refers to the field of human medicine, and specifically to the diagnosis of the tolerant state in liver transplant recipients. More precisely, the present invention concerns a method for the in vitro diagnosis of a liver graft tolerant or non- tolerant phenotype, comprising: (a) determining from a liver grafted subject biological sample an expression profile comprising the 25 genes of Table 1, (b) comparing the obtained expression profile with at least one reference expression profile, and (c) determining the graft tolerant or graft non-tolerant phenotype from said comparison. The present invention also relates to kits and nucleic acid microarrays for performing said method. The present invention also relates to a method of treatment of liver transplant recipient.