| 摘要 |
The present invention relates to a class of compounds and to diagnostic compositions containing such compounds where the compounds are iodine containing compounds. More specifically the iodine containing compounds are chemical compounds containing two linked iodinated phenyl groups of the general formula (I): R—CO—N(R)—X—N(R)—CO—R and salts or optical active isomers thereof, wherein one R denotes a hydrogen atom or a C1 to C5 straight or branched alkyl group optionally substituted by 1 to 4 —OH groups, and the other R1 denotes a C1 to C5 straight or branched alkyl group substituted by 1 to 4 —OH groups; X denotes an alkylene moiety with 3 to 10 carbon atoms substituted by 1 to 6 OH groups and where up to 3 carbon atoms optionally are replaced by oxygen atoms; and each R independently are the same or different and denote a triiodinated phenyl group, preferably a 2,4,6-triiodinated phenyl group further substituted by two groups RA wherein each RA are the same or different and denote a hydrogen atom or a non-ionic hydrophilic moiety, provided that at least one RA group in the compound of formula (I) is a hydrophilic moiety. The invention also relates to the use of such diagnostic compositions as contrast agents in diagnostic imaging and in particular in X-ray imaging, and to contrast media containing such compounds.
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