发明名称 |
ASYMMETRIC CYCLOPROPANATION WITH SUCCINIMIDYL DIAZOACETATE |
摘要 |
Cobalt(ll) complexes of the D 2-symmetric chiral porphyrins are effective catalysts for asymmetric cyclopropanation reactions with succinimidyl diazoacetate. The Co-catalyzed reaction is suitable for various olefins, providing the corresponding cyclopropane succinimidyl esters in high yields and excellent diastereo- and enantio-selectivity. The resulting enantioenriched cyclopropane succinimidyl esters can serve as convenient synthons for the general synthesis of optically active cyclopropyl carboxamides through mild reactions with a wide range of amine derivatives, including unprotected peptides and amino sugars |
申请公布号 |
WO2010094029(A3) |
申请公布日期 |
2010.12.02 |
申请号 |
WO2010US24299 |
申请日期 |
2010.02.16 |
申请人 |
UNIVERSITY OF SOUTH FLORIDA;ZHANG, X. PETER;RUPPEL, JOSHUA V. |
发明人 |
ZHANG, X. PETER;RUPPEL, JOSHUA V. |
分类号 |
C07C233/57;B01J31/24;C07C231/18;C07D207/46 |
主分类号 |
C07C233/57 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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