发明名称 |
COMPOSITIONS AND METHODS FOR SHORT INTERFERING NUCLEIC ACID INHIBITION OF NAV1.8 |
摘要 |
The invention provides short interfering nucleic acids, either single-stranded or double-stranded, that cause RNAi-induced degradation of mRNA from the Nav1.8 sodium channel gene; to pharmaceutical compositions comprising such short interfering nucleic acids; recombinant vectors comprising such short interfering nucleic acids; a method for inhibiting translation of an mRNA; a method for inhibiting expression of a polypeptide; a method for blocking the membrane potential in a cell; a method for blocking the sodium current in a cell; and a method for inhibiting chronic pain.
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申请公布号 |
US2010305192(A1) |
申请公布日期 |
2010.12.02 |
申请号 |
US20100789564 |
申请日期 |
2010.05.28 |
申请人 |
SCHERING CORPORATION;CANJI, INC. |
发明人 |
GOREGAOKER SAMEER;HUNTER JOHN C.;PRIESTLEY TONY |
分类号 |
A61K31/7088;A61P29/00;C07H21/00;C07H21/04;C12N5/071;C12N15/113;C12N15/63 |
主分类号 |
A61K31/7088 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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