| 发明名称 |
DI-ESTER PRODRUGS OF CAMPTOTHECIN, PROCESS FOR THEIR PREPARATION AND THEIR THERAPEUTICAL APPLICATIONS |
| 摘要 |
The present invention is related to 10,20-di-O ester derivatives of camptothecin and pharmaceutical formulations thereof. The compounds and pharmaceutical formulations of the present invention possess increased biological life span and bioavailability and reduced toxicity, while maintaining anti-cancer activity.
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| 申请公布号 |
US2010305148(A1) |
申请公布日期 |
2010.12.02 |
| 申请号 |
US20100759144 |
申请日期 |
2010.04.13 |
| 申请人 |
ABRAXIS BIOSCIENCE, LLC |
发明人 |
SOON-SHIONG PATRICK;DESAI NEIL P.;TAO CHUNLIN;YU CHENG ZHI |
| 分类号 |
A61K31/4375;A61K31/4745;A61P35/00;A61P35/02;C07D491/22 |
主分类号 |
A61K31/4375 |
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