| 发明名称 |
CHEMICALLY MODIFIED SMALL MOLECULES |
| 摘要 |
The invention provides small molecule drugs that are chemically modified by covalent attachment of a water-soluble oligomer obtained from a monodisperse or bimodal water-soluble oligomer composition. A conjugate of the invention, when administered by any of a number of administration routes, exhibits a reduced biological membrane crossing rate as compared to the biological membrane crossing rate of the small molecule drug not attached to the water-soluble oligomer.
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| 申请公布号 |
US2010305147(A1) |
申请公布日期 |
2010.12.02 |
| 申请号 |
US20100822935 |
申请日期 |
2010.06.24 |
| 申请人 |
NEKTAR THERAPEUTICS |
发明人 |
BENTLEY MICHAEL D.;VIEGAS TRACEY X.;GOODIN RICHARD R.;CHENG LIN;ZHAO XUAN |
| 分类号 |
A61K31/485;A61K31/765;A61K31/785;A61K47/48;A61P3/00;A61P7/02;A61P11/00;A61P19/02;A61P21/02;A61P29/00;A61P31/00;A61P33/00;A61P35/00;C07D489/02;C08G65/08 |
主分类号 |
A61K31/485 |
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