| 摘要 |
PROBLEM TO BE SOLVED: To provide a solid formulation of raloxifene. SOLUTION: The solid formulation of raloxifene is produced by purifying a solid inclusion complex of raloxifene hydrochloride andβ-cyclodextrin by (A) a step to dissolve raloxifene hydrochloride in an aqueous solution, (B) a step to heat the obtained mixture at a temperature between 50°C and 80°C, (C) a step to addβ-cyclodextrin and (D) a step to separate the raloxifene hydrochloride-β-cyclodextrin complex by precipitation and filtration. COPYRIGHT: (C)2011,JPO&INPIT
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