SILANE-FUNCTIONALIZED HYDROPHOBIC a(1-4)GLUCOPYRANOSE POLYMERS AND POLYMERIC MATRICES FOR IMPLANTATION OR INJECTION

摘要

Silane-functionalized hydrophobicα(1→4)glucopyranose polymers and polymeric matrices are described. Biodegradable matrices can be formed from hydrophobicα(1→4)glucopyranose polymers with reactive pendent silyl ether groups. Reaction of the silyl ether groups provides improved matrix formation through bonding to a device surface of a device, polymer-polymer crosslinking, or both. Biodegradable matrices can be used for the preparation of implantable and injectable medical devices, including those that release a bioactive agent.