HYALURONIDASE AS AN ADJUVANT FOR INCREASING THE INJECTION VOLUME AND DISPERSION OF LARGE DIAMETER SYNTHETIC MEMBRANE VESICLES CONTAINING A THERAPEUTIC AGENT

摘要

Embodiments of the invention relate to hyaluronidase as an adjuvant to increase the injection volume and dispersion of large diameter synthetic membrane vesicles containing one or more therapeutic agents. In particular, embodiments of the invention relate to compositions comprising hyaluronidase and large diameter synthetic membrane vesicles containing a therapeutic agent, and methods of administration of the same. Methods of making large diameter synthetic membrane vesicles containing an active pharmaceutical ingredient and their use in combination with hyaluronidase as medicaments are provided.