PROCÉDÉ IN VITRO APPROPRIÉ POUR DES PATIENTS SOUFFRANT D'UN SYNDROME CLINIQUE ISOLÉ POUR LE DIAGNOSTIC PRÉCOCE OU LE PRONOSTIC DE LA SCLÉROSE EN PLAQUES

摘要

In vitro method suitable for patients suffering from CIS for the early diagnosis or prognosis of multiple sclerosis. The method comprises the identification of the up- regulation of the CHI3L1 protein or gene in CSF samples isolated from those patients suffering from CIS. Furthermore the invention refers to a method for screening or identifying compounds or molecules active for treating those patients suffering from MS, to kits for the early diagnosis of MS or for the prognosis of MS disability progression in patients suffering from CIS and to a pharmaceutical composition comprising a therapeutically effective amount of an agent, active for inhibiting the activity of the CHI3L1 protein or the expression of the CHI3L1 gene.