发明名称 |
TRIMETHYLAMINE COMPOUNDS AS RISK PREDICTORS OF CARDIOVASCULAR DISEASE |
摘要 |
Methods of characterizing a test subject's risk of having or developing cardiovascular disease are provided. The methods include using an analytic device to determine levels of choline-related trimethylamine-containing compounds such as trimethylamine N-oxide, choline, or betaine in a biological sample obtained from the subject and comparing the levels of the choline-related trimethylamine-containing compound in the subject's biological sample to a control value. The test subject's risk of having cardiovascular disease is then characterized as higher if the levels of the choline-related trimethylamine-containing compound are higher than the control value. Also provided are methods of identifying a subject at risk of experiencing a complication of atherosclerotic cardiovascular disease, and methods of evaluating the efficacy of a cardiovascular therapeutic agent in a subject with cardiovascular disease using levels of choline-related trimethylamine-containing compounds. |
申请公布号 |
EP2222220(A4) |
申请公布日期 |
2010.12.01 |
申请号 |
EP20080857358 |
申请日期 |
2008.12.05 |
申请人 |
THE CLEVELAND CLINIC FOUNDATION |
发明人 |
HAZEN, STANLEY, L.;WANG, ZENENG;LEVISON, BRUCE, S. |
分类号 |
A61B5/00;G01N33/92 |
主分类号 |
A61B5/00 |
代理机构 |
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