发明名称 |
POLYMER CONJUGATE OF PHYSIOLOGICALLY ACTIVE SUBSTANCE |
摘要 |
Disclosed is a water-soluble high-molecular weight conjugate of physiologically active substances which enable medicament to release without depending on the enzymes in a living body and which is expected to have a useful therapeutic effect. A high-molecular weight conjugate of a physiologically active substance has a substituent group represented by a general formula (1) bonded to a side-chain carboxy group of a block copolymer which has a polyethylene glycol moiety and either a polyaspartic acid moiety or a polyglutamic acid moiety. Formula (1): -Ar-CR15R16-O-C(=O)-A [In the formula: Ar represents an aromatic hydrocarbon group optionally a substituent group, or an aromatic heterocyclic group optionally having a substituent group; R15 and R16 independently represent a hydrogen atom or a (C1-C6) alkyl group optionally having a substituent group; and A represents a residual group of a physiologically active substance that has an carboxy group, or a residual group of a physiologically active substance that has an amino group]. |
申请公布号 |
KR20100126378(A) |
申请公布日期 |
2010.12.01 |
申请号 |
KR20107020425 |
申请日期 |
2009.03.17 |
申请人 |
NIPPON KAYAKU KABUSHIKI KAISHA |
发明人 |
KITAGAWA MASAYUKI;SENO CHIEKO |
分类号 |
A61K47/48;A61K31/352;A61P29/00;C08G69/48 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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