发明名称 |
Methods of therapy for cancers expressing the CD40 antigen |
摘要 |
Methods of treating a subject for a cancer comprising neoplastic cells expressing the CD40 cell surface antigen are provided. The methods comprise combination therapy with interleukin-2 (IL-2) or biologically active variant thereof and at least one antagonist anti-CD40 antibody or antigen-binding fragment thereof. In some embodiments, these two therapeutic agents are concurrently administered as two separate pharmaceutical compositions, one containing IL-2 or biologically active variant thereof, which is administered according to a constant IL-2 dosing regimen or a two-level IL-2 dosing regimen, the other containing the antagonist anti-CD40 antibody or suitable antigen binding fragment thereof, which is administered according to a weekly dosing regimen, or alternatively is dosed once every two, three, or four weeks.; Administering of these two agents together potentiates their effectiveness in promoting a positive therapeutic response. The methods find use in treating CD40-expressing cancers, including B-cell related cancers and solid tumors. |
申请公布号 |
EP2255828(A1) |
申请公布日期 |
2010.12.01 |
申请号 |
EP20100006780 |
申请日期 |
2004.11.04 |
申请人 |
NOVARTIS VACCINES AND DIAGNOSTICS, INC.;XOMA TECHNOLOGY LTD. |
发明人 |
LONG, LI;LUQMAN, MOHAMMAD;YABANNAVAR, ASHA;ZAROR, ISABEL;HURST, DEBORAH;LOPES DE MENEZES, DANIEL E. |
分类号 |
A61K39/395;A61K38/20;A61P35/02;C07K16/28 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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