| 发明名称 |
Bioconjugation of macromolecules |
| 摘要 |
This invention discloses a novel method for conjugating macromolecules to other molecular entities. Specifically, this invention discloses a method for conjugating or derivatizing macromolecules, such as oligonucleotides and proteins, using cycloaddition rections, such as the Diels-Alder reaction or 1,3-dipolar cycloadditions. Included in the invention are the novel bioconjugated macromolecules that can be prepared according to the method of the invention. |
| 申请公布号 |
EP2256133(A1) |
申请公布日期 |
2010.12.01 |
| 申请号 |
EP20100007407 |
申请日期 |
1998.01.08 |
| 申请人 |
SIGMA-ALDRICH CO. |
发明人 |
PIEKEN, WOLFGANG;HILL, KEN;EATON, BRUCE;MCGEE, DANNY;VAGLE, KURT;GOLD, LARRY;STEPHENS, ANDREW |
| 分类号 |
C07H19/067;C07K19/00;C07H19/04;C07H19/10;C07H19/20;C07H21/00;C07H21/02;C07H21/04;C08G65/329;C08G85/00;C12N15/09;C12N15/113;C12P19/34;C12Q1/68 |
主分类号 |
C07H19/067 |
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