发明名称 |
ANTHRANILIC ACID AMIDES WITH A HETEROARYLSULFONYL SIDE CHAIN, METHOD FOR THE PRODUCTION THEREOF, USE THEREOF AS A MEDICAMENT OR A DIAGNOSTIC AGENT AND PHARMACEUTICAL PREPARATIONS CONTAINING SAID COMPOUNDS |
摘要 |
The invention relates to compounds of formula (I), wherein R(1) -R(7) have the meanings cited in the claims. Said compounds act upon the Kv1.5-potassium channel and inhibit a potassium flow in the atrium of the human heart, designated as an ultra-rapidly activating delayed rectifier. As a result, they are particularly suitable for use as novel antiarrhythmic active substances, especially in the treatment and prophylaxis of atrial arrhythmia, e.g. atrial fibrillation (AF) or atrial flutter.
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申请公布号 |
CA2450076(C) |
申请公布日期 |
2010.11.30 |
申请号 |
CA20022450076 |
申请日期 |
2002.05.31 |
申请人 |
AVENTIS PHARMA DEUTSCHLAND GMBH |
发明人 |
BRENDEL, JOACHIM;BOEHME, THOMAS;PEUKERT, STEFAN;KLEEMANN, HEINZ-WERNER |
分类号 |
C07D215/36;A61K31/33;A61K31/42;A61K31/4245;A61K31/4402;A61K31/47;A61K31/472;A61K31/497;A61K45/06;A61P9/06;C07D213/70;C07D213/71;C07D217/02;C07D261/10;C07D271/12;C07D333/34;C07D401/12;C07D405/12 |
主分类号 |
C07D215/36 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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