发明名称 |
Method of manufacture of zaleplone |
摘要 |
The invention relates to a process for the preparation of zaleplon (N-[3(3-cyanopyrazolo[1,5-a]pyrim-idin-7-yl)phenyl]-N-ethyl-accramide) in the reaction of 3-dimethylamino-1-(3-N-ethyl-N-acetylamirnophenyl)-2-propen-1-one with 3-aminopyrazole-4-carbonitrile, which comprises carrying out said reaction in an aqueous solution of formic acid at formic acid concentrations in the range of 20-80% (w/w). Zaleplon is useful as an anxiolytic, a sedactive and a skeletal muscle relaxant. |
申请公布号 |
PL207322(B1) |
申请公布日期 |
2010.11.30 |
申请号 |
PL20020353870 |
申请日期 |
2002.05.14 |
申请人 |
ADAMED SPO&LSTROK,KA Z OGRANICZON&AOGON, ODPOWIEDZIALNO&SACUTE,CI&AOGON, |
发明人 |
WIECZOREK MACIEJ;STAWI&NACUTE,SKI TOMASZ;KORYCI&NACUTE,SKA MONIKA |
分类号 |
C07D487/04;A61P21/02;A61P25/20;A61P25/22 |
主分类号 |
C07D487/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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