A PROCESS FOR PREPARING 5-[(R)-2-(5,6-DIETHYL-INDAN-2-YLAMINO)-1-HYDROXY-ETHYL]-8-HYDROXY-(1H)-QUINOLIN-2-ONE SALTS, USEFUL AS ADRENORECEPTOR AGONISTS

摘要

A PROCESS FOR PREPARING 5-[(R)-2-(5,6-DIETHYL-INDAN-2-YLAMINO)-1-HYDROXY-ETHYLJ-S-HYDROXY(1H)-QUINOLIN-2-ONE SALT. THE PROCESS INVOLVES FORMING AN ACID SALT OF 5-[(R)-2-(5,6-DIETHYLINDAN-2-YLAMINO )-L-HYDROXY-ETHYIJ-S-SUBSTITUTED OXY-(L H)-QUINOLIN-2-ONE; AND CONVERTING THE ACID SALT TO A SALT OF 5-[(R)-2-(5,6-DIETHYL-INDAN-2-YLAMINO)-1-HYDROXY-ETHYLJ-8-HYDROXY(1H)-QUINOLIN-2-ONE WITHOUT ISOLATING THE FREE BASE OF 5-[(R)-2-(5,6-DIETHYL-INDAN-2YLAMINO)-L-HYDROXY-ETHYIJ-S-HYDROXY-( 1 H)-QUINOLIN-2-ONE.