ORAL DOSAGE FORMS FOR PROPIVERINE OR ITS PHARMACEUTICALLY ACCEPTABLE SALTS WITH AN EXTENDED RELEASE OF THE ACTIVE INGREDIENT

摘要

BY SUITABLE RETARDATION ORAL PHARMACEUTICAL COMPOSITIONS CONTAINING PROPIVERINE OR ONE OR SEVERAL PHARMACAUTIALLY ACCEPTABLE SALTS THEREOF IN AN AMOUNT OF 4mg TO 60mg PROPIVERINE AND HAVING A PROLONGED RELEASE OF THE ACTIV E AGENT ARE PRODUCED. PREFERABLY ABLEND OF ACTIVE AGENT AND AT LEAST ONE OR MORE ACIDIC SUBSTANCES HAVING A pKa VALUE OF LESS THAN 6.65 ARE PROVIDED WITH A RETARDINBG COATING OR ARE EMBEDDED IN A MATRIX WHICH IS THEN OPTIONALLY COATED WIT FURTHER RETARDING LAYERS.